Q30. For which of the following disease, the transgenic
animal model has not been developed?
(a) Cancer
(b) Cystic Fibrosis
(c) AIDS
(d) Alzheimer's disease

Question

FirstInTest · Accepted Answer

Correct answer: c. Transgenic animal models are developed to mimic human diseases, allowing researchers to study disease progression, gene function, and test potential therapies. Models have been successfully developed for a wide range of human diseases:
*   **Cancer:** Transgenic mice are extensively used to study various types of cancer by introducing oncogenes or knocking out tumor suppressor genes.
*   **Cystic Fibrosis:** Transgenic mouse models have been created to study cystic fibrosis by manipulating the CFTR gene.
*   **Alzheimer's disease:** Transgenic mouse models expressing human genes associated with Alzheimer's are commonly used to investigate disease mechanisms and drug candidates.
*   **AIDS (Acquired Immunodeficiency Syndrome):** Developing a fully representative transgenic animal model for AIDS has been particularly challenging. The Human Immunodeficiency Virus (HIV) primarily infects human cells and does not efficiently infect the cells of typical laboratory animals like mice. While 'humanized' mice (engineered to have human immune cells) have been developed, a complete and robust transgenic animal model to fully replicate HIV infection and AIDS progression as seen in humans is still a significant challenge.

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